Personal Statement

In the past 20+ years my research interest has been the extracellular matrix and especially cell - basement membrane - interactions. The elucidation of the pathogenesis of osteoarthritis has also played a large role. Major contributions were to the molecular composition of basement membranes, as well as the discovery of chondrogenic progenitor cells (Cell Stem Cell, 2009) in late stages of osteoarthritis. Meanwhile, we have identified further chondrogenic progenitor cells in osteoarthritic human meniscus, cartilage from human rheumatoid arthritis and osteoarthritis of the TMJ in a mouse model. Currently, I am investigating the signal transduction pathways of these cells, to find cues to utilize them for cartilage regeneration.

CV (incl. Positions and Employment)

Mar. 2007	End of temporary principalship of the Institute for Histology
Oct. 2006	Principalship at the Oral Biology and Tissue Regeneration Work Group
Nov. 2005	Temporary principalship of the Institute for Histology
Jan. 2005	Full Professor at the Medical Faculty
May 2002	Appointment to Associate Professor at the Department of Anatomy
Nov. 2000	Postdoctural lecturing qualification for Anatomy
Jan. 1999	Specialist for Anatomy
1997	Research Fellow, Cutaneous Biology Research Center, Prof. Dr. R.E. Burgeson, Harvard Medical School, Boston, USA
1994 - 1995	Doctor at practical training
1994	Doctorate for human medicine, thesis: Ultrastructural localization of laminin and three of its subunits in the kidney and the embryo

Professional Memberships

Anatomical Society, German Society for Matrix Research, European Teratology Society, International Society Matrix Biology (ISMB), Osteoarthriris Research Society International (ORSI), German Society for Osteology (DGO), Work Group for Science in Dentistry (AfG) in the DGZMK

Since 2017 re-elected speaker of the Senate of the Georg-August-University Goettingen

Since 2015 elected speaker of the Senate of the Georg-August-University Goettingen

Since 2009 elected senator of the Georg-August-University Goettingen

In the Medical Faculty, member of the commissions for postdoctural lecturing qualification, students admission, library and examinations Major Publications

Schminke B, Trautmann S, Mai B, Miosge N, Blaschke S (2015) Interleukin17 inhbits progenitor cells in rheumatiod arthritis. Eur J Immunol. [Epub ahead of print].

Schminke B, Frese J, Bode C, Goldring MB, Miosge N (2015) Laminins and Nidogens in the Pericellular Matrix of Chondrocytes: Their Role in Osteoarthritis and Chondrogenic Differentiation. Am J Pathol. [Epub ahead of print].

Rais Y, Reich A, Simsa-Maziel S, Moshe M, Idelevich A, Kfir T, Miosge N, Monsonego-Ornan E (2015) The growth plates response to load is partially mediated by mechano-sensing via the chondro-cytic primary cilium. Cell Mol Life Sci 72:597-615.

Muhammad H, Schminke B, Bode C, Roth M, Albert J, von der Heyde S, Rosen V, Miosge N (2014) Human migratory meniscus progenitor cells are controlled via the TGF-β pathway. Stem Cell Reports 3:789-803.

Schminke B, Muhammad H, Bode C, Sadowski B, Gerter R, Gersdorff N, Bürgers R, Monsonego-Ornan E, Rosen V, Miosge N (2014) A discoidin domain receptor 1 knock-out mouse as a novel model for osteoarthritis of the temporomandibular joint. Cell Mol Life Sci 71:1081-96.

Koelling S, Miosge N (2010) Sex differences of chondrogenic progenitor cells in late stages of osteo-arthritis. Arthritis Rheum 62:1077-87.

Koelling S, Kruegel J, Irmer M, Path J, Sadowski B, Miró X, Miosge N (2009) Migratory chondrogenic progenitor cells from repair tissue during the late stages of human osteoarthritis. Cell Stem Cell 4:324-335. Ongoing Research Support

DFG - Mi ⁵⁷³⁄₁₀-2: Progenitor cells in osteoarthritis for cartilage repair in humans (2016 - 2019).

Completed Research Support (selected)

DFG - Mi ⁵⁷³⁄₁-2: Investigation of the molecular arrangement of the basement membrane components laminin, nidogen-1 and collagen type IV in vivo (1997 – 2000). DFG - Mi ⁵⁷³⁄₂-1: Expression of collagen type XVIII and its anti- angiogen c-teminal domaine endostatin (1999 – 2001). DFG - Mi ⁵⁷³⁄₁-3: Ultrastructural investigation of basement membranes in muscle and blood vessels (2000 - 2001). Intern. Post Doc Program: Matrix alterations in liver fibrosis - Dr. Lisa Morio, Rutgers University (2000 – 2001). DGI: to Dr. N. Gersdorff, Microarray analysis of human parodontitis tissue in vivo (2006 - 2007). German Arthrosis Society: to Prof. Dr. W. Schultz: Role of fibroblast-like chondrocytes in osteoarthritis (2006 –2008). DFG - BA ³³³⁄₁-1: Integration after re-fixation of rotor cuff ruptures with a single- and double-row-technique (2008 –2010). DFG summer school GZ 677 in Xi`an, China: Stem cells in development and regeneration in oral and maxillio-facial tissues (2011). DFG - Mi ⁵⁷³⁄₁₀-1: Progenitor cells in osteoarthritis and rheumatoid arthritis for cartilage repair in humans (2012 - 2015). DFG - IMMUNOBONE: Molecular mechanisms of IL 17/ Th17 T cell function on cartilage and bone matrix destruction in rheumatoid arthritis and its modulation via osteopontin (2010 – 2013).

International Cooperations

Prof. Dr. Vicki Rosen, Developmental Biology, Harvard, Boston Prof. Dr. Efrat Monsonego-Ornan, Biochemistry, Rehovot, Israel Prof. Dr. Mary Goldring, Hospital for Special Surgery, New York, USA

Referee

German Research Foundation (DFG), The Netherlands Organization for Scientific Research, Wellcome Trust, Swiss Science Foundation, Bavarian Research Society, Arthritis UK, BMC.